Dr. Howard Smith Oncall

Vidcast: https://www.instagram.com/p/C5WwxNsrj1h/ The next generation of Moderna’s mRNA CoVid vaccines will be directed against two key portions of the virus’ spike protein rather than the entire spike.  Creating mRNA that codes only for the spike’s N-terminal domain (NTD) and the receptor binding domain (RBD) generates blocking antibodies against these two spike regions that play the greatest roles in viral attachment to human cells.  As a result, this improved vaccine will be more active against variants and subvariants that pop up. The other good news about this new vaccine family, dubbed mRNA-1283 in contrast to the initial Moderna offering labeled mRNA 1273, is that it offers enhanced stability in the refrigerator vs. the freezer.  In addition, the new vaccine is effective at lower doses with fewer potential side effects. Look for this new Moderna offering in the fall. https://medicalxpress.com/news/2023-09-moderna-reveals-highly-covid-vaccine.html #moderna #CoVid #vaccine #mRNA #NTD #RBD #stability