Collège De France (général)

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2023-2024Exploring the World of Protein Post-translational ModificationsConférence - Tony Hunter : Crosstalk between Post-translational Modifications: The Role of Ptm Crosstalk in Protein DegradationTony HunterSalk Institute, La Jolla, California, USARésuméIn this lecture I will discuss the role of PTMs in increasing proteome complexity, why this is important for organisms with genomes of limited protein-coding capacity, and how the combinatorial use of PTMs on a single protein molecule can diversify signal outputs. I will go on to discuss examples of crosstalk between different PTMs in the context of transcriptional regulation mediated by posttranslational modifications of histone tails, and how different PTMs can be used to tag proteins for inducible degradation by the ubiquitin-proteasome system (UPS).The modification of proteins by ubiquitin and ubiquitin-like proteins, such as SUMO, is second only to phosphorylation in terms of the nu